Spain will be without Barcelona winger Lamine Yamal and Real Sociedad forward Mikel Oyarzabal for Thursday's UEFA Nations League encounter against the Czech Republic, although both players are expected to return ahead of Sunday's clash with England.
The Spanish Football Federation (RFEF) confirmed on Monday that Yamal reported discomfort in his right knee following Barcelona's 2-1 LaLiga victory over Atletico Madrid on Sunday.
Meanwhile, Oyarzabal is recovering from a bout of flu and remains in the final stages of his recovery.
Despite their absence from Thursday's fixture, the federation expects both players to join Spain's training camp in the coming days.
"Both players will join the training camp in the coming days so they can be available to face England at the Metropolitano Stadium (on Sunday)," the RFEF confirmed.
Spain have already secured qualification for the UEFA Nations League quarter-finals, easing the immediate pressure ahead of their remaining fixtures.
The reigning world champions will travel to face the Czech Republic on Thursday before returning to Madrid to host Thomas Tuchel's England at the Metropolitano Stadium on Sunday.
The potential return of Yamal and Oyarzabal would provide Spain with additional attacking options for their highly anticipated meeting with England.
